Francis Godolphin (died 1652), of Treveneage in Cornwall, was an English Member of Parliament. The son of Sir William Godolphin of Treveneage, he represented St Ives in the Parliament of 1628-9 and again in the Long Parliament. Unlike his relatives in the senior branch of the Godolphin family, he supported the Parliamentary cause on the outbreak of the Civil War, and continued to sit through most of the 1640s; however, there is no record of his having taken any part in proceedings after Pride's Purge. (He should not be confused with his namesake and cousin once removed, Francis Godolphin of Godolphin, who was also a member of the Long Parliament but was ejected as a Royalist in 1644.)

Godolphin married Ann Carew in 1616, and they had three children:

Francis Godolphin of Crowan
Catherine Godolphin, who married John St Aubyn of Clowance
Loveday Godolphin
He died in 1652, and was buried on 4 February 1652 at Crowan.